Share a compound : 7-Bromo-1-heptene

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-Bromo-1-heptene, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 4117-09-3, name is 7-Bromo-1-heptene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4117-09-3, Safety of 7-Bromo-1-heptene

Typical procedure for the preparation of Grignard reagent: To a suspension of magnesium (0.13g, 5.32mmol) in anhydrous THF (1mL) was added dropwise 1-bromobutane (0.1g, 0.71mmol) at room temperature under an argon. After the reaction started, a THF solution of the remaining 1-bromobutane (0.57g, 4.19mmol/anhydrous THF 4mL) was dropwise into the reaction mixture at that temperature. After stirring for 50min, 0.8M of n-BuMgBr in THF was obtained. (The concentration was determined by the titration experiment.) (0038) Method A: To a suspension of CuCN (0.059g, 0.66mmol) in anhydrous THF (1mL) was added dropwise a THF solution of n-BuMgBr (0.8M, 0.83mL, 0.66mmol, prepared from n-BuBr and magnesium) at -78C under argon. After stirring for 5min, the mixture was warmed to -10C, and then stirred for 10min. The reaction mixture was again cooled to -40C, and to this mixture was added dropwise a solution of (E)-diethyl 2-fluoro-3-phenyl-2-propenylphosphate (0.086g, 0.3mmol) in anhydrous THF (2mL). After 15min, the reaction was quenched with an aqueous saturated NH4Cl solution and the whole was extracted with diethyl ether. The combined organic layers were dried over anhydrous Na2SO4, concentrated in vacuo. The residue was purified by silica gel column chromatography to give 2-fluoro-3-phenyl-1-heptene (13a) (quant., 19F NMR yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-Bromo-1-heptene, and friends who are interested can also refer to it.

Reference:
Article; Nihei, Takashi; Kubo, Yusuke; Ishihara, Takashi; Konno, Tsutomu; Journal of Fluorine Chemistry; vol. 167; (2014); p. 110 – 121;,
Bromide – Wikipedia,
bromide – Wiktionary