Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 65185-58-2, name is 2-Bromophenethylamine, A new synthetic method of this compound is introduced below., category: bromides-buliding-blocks
4m was then obtained by following the general procedure. A solution of compound 3 (160 mg, 0.81 mmol) in n-BuOH (6 mL) was treated with DIEA (114 mg, 0.89 mmol) and 2-chlorophenethylamine (162 mg, 0.81 mmol). Compound 4m was purified from this crude material by column chromatography (silicagel, n-hexane/EtOAc=3:1) (118.6 mg, 40.1%). 1H-NMR (400 MHz, DMSO-d6) delta 8.88 (t, J=5.2 Hz, 1H, N-H), 8.21 (d, J=7.6 Hz, 1H), 7.79 (t, J=8.4 Hz, 1H), 7.58 (t, J=15.6 Hz, 2H), 7.52 (t, J=8.4 Hz, 1H), 7.40-7.26 (m, 2H), 7.16 (td, J=8.6, 2.0 Hz, 1H), 3.70-3.60 (m, 2H, -CH2-), 3.11 (t, J=7.6 Hz, 2H, -CH2-). 13C-NMR (100 MHz, DMSO-d6) delta161.6, 157.4, 150.7, 138.8, 134.1, 133.0, 131.6, 129.0, 128.3, 127.1, 126.6, 124.5, 123.5, 114.0, 41.2, 34.8; LRMS (ESI) m/z: 363.2 ([M+H]+).
The synthetic route of 65185-58-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; The Board of Regents of the University of Oklahoma; Wang, Weidong; Lee, Jae Wook; (35 pag.)US2019/47988; (2019); A1;,
Bromide – Wikipedia,
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