Synthetic Route of 2924-09-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2924-09-6, name is 5-Bromo-2-fluoroaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
In an argon atmosphere, 106 mL of water was added to 10g of 5-bromo-2-fluoroaniline, and the mixture wasstirred, followed by addition of 79.2 mL of concentrated hydrochloric acid. The resulting mixture was cooled in ice, andan aqueous solution of 4.36g of sodium nitrate was added dropwise. While cooling in ice, the resultant was stirred for30 minutes, and then an aqueous solution of 87.3g of potassium iodide was added. After extraction with ethyl acetate,an organic layer was washed with an aqueous solution of a saturated sodium hydrogen carbonate and an aqueoussolution of sodium sulfite and dried with magnesium sulfate. Then, the solvent was distilled off under reduced pressure.Residues were purified by silica gel column chromatography, whereby 11.5g (yield: 73%) of 5-bromo-2-fluoroiodebenzenewas obtained.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-2-fluoroaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Idemitsu Kosan Co., Ltd; ITO, Hirokatsu; SAITO, Hiroyuki; MIZUKI, Yumiko; KAWAMURA, Masahiro; EP2924029; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary