These common heterocyclic compound, 327-52-6, name is 1-Bromo-2,4,5-trifluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C6H2BrF3
EXAMPLE 1 2,4,5-Trifluorobenzoic Acid To a stirred suspension, under argon, of 9 g of magnesium chips in 150 ml of tetrahydrofuran containing a crystal of iodine and cooled to 0 C. was added a solution of 60 g of 2,4,5-trifluorophenyl bromide in 80 ml of tetrahydrofuran dropwise over 1.5 hours. The temperature was kept below 35 C. during the addition and kept at 35 C. for an additional hour then cooled to 0 C. A gentle stream of carbon dioxide was bubbled through the reaction mixture for one hour at 0 C., one hour at room temperature and one hour at reflux. The reaction mixture was cooled to 0 C. and poured into a beaker containing 300 ml of 2N hydrochloric acid and 200 ml of ice water. The aqueous mixture was filtered and the filtrate extracted with 3*335 ml of methylene chloride. The combined organic extracts were dried and the volatiles removed in vacuo to give 49.4 g of the desired compound. Crystallization from hexanes gave the desired product as light yellow crystals, mp 92-95 C.
The synthetic route of 1-Bromo-2,4,5-trifluorobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; American Cyanamid Company; US4923868; (1990); A;,
Bromide – Wikipedia,
bromide – Wiktionary