Adding a certain compound to certain chemical reactions, such as: 86845-27-4, name is 5-Bromo-2-methylbenzotrifluoride, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 86845-27-4, Safety of 5-Bromo-2-methylbenzotrifluoride
A mixture of 4-methyl-3-trifluorobromobenzene (25 g, 104.59 mmol), N-bromosuccinimde (18.62 g, 104.59 mmol) and benzoyl peroxide (1.27 g, 5.23 mmol) in CCI4 (35 mL) was heated at 90 C for 4 hours. The reaction mixture was cooled to 0 C and then filtered through a glass frit washing with CH2CI2. The filtrate was concentrated and then purified by flash column chromatography (0% to 5% EtOAc in hexanes) to give the product as a clear oil that crystallized on standing (33.26 g, 100%). 1H NMR (400 MHz, CDCI3) 5 4.57 (s, 2H), 7.46 (d, J=8.3 Hz, 1 H), 7.67 (d, J=8.3 Hz, 1 H), 7.78 (s, 1H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-2-methylbenzotrifluoride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER INC.; WO2006/18725; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary