In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13633-25-5 as follows. Recommanded Product: 1-Bromo-4-phenylbutane
General procedure: To a solution of 4a-4e (0.1 mmol) in dry DCM (5 mL) was addedDIPEA (0.17 mmol) in a Schlenk tube. The tube was screwed down,stirred and heated at 75 C for 10 min, and the reaction mixturewas cooled to room temperature and benzyl bromide (1.7 mmol)was added to the solution. The reaction mixture was stirred andheated at 75 C for 48 h. After cooling the mixture, silica gel wasadded to the crude mixture, the solvent was evaporated underreduced pressure and the residue was purified by flash chromatography with a mixture of hexanes/EtOAc/TEA (95:5:1).
According to the analysis of related databases, 13633-25-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Djigoue, Guy Bertrand; Kenmogne, Lucie Carolle; Roy, Jenny; Maltais, Rene; Poirier, Donald; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5433 – 5451;,
Bromide – Wikipedia,
bromide – Wiktionary