Application of 3814-30-0, The chemical industry reduces the impact on the environment during synthesis 3814-30-0, name is (Bromomethyl)cyclopentane, I believe this compound will play a more active role in future production and life.
Under the protection of nitrogen, the future nalidamine derivative (0.1 mmol),Sodium metabisulfite (0.2mmol, 2.0equiv.), Tin powder (0.3mmol, 3.0equiv.),1,1′-bis (diphenylphosphino) ferrocene palladium dichloride (0.01mmol, 10mol%), 1,1′-bis (diphenylphosphine) ferrocene (0.02mmol, 20mol%) , Dipotassium hydrogen phosphate trihydrate (0.2 mmol, 2.0 equiv.), And tetrabutylammonium bromide (0.15 mmol, 1.5 equiv.) Were added to a reaction tube containing magnetons,After evacuation of nitrogen for three times, bromomethylcyclopentane (0.3 mmol, 3.0 equiv.) And DMSO (1.0 mL) were added, and the reaction system was heated to 100 C for 10 hours.After detecting the complete conversion of aryl iodide on the plate, the reaction system was cooled to room temperature, diluted with water, and extracted with ethyl acetate (10 mL * 3), dried over anhydrous sodium sulfate, filtered, concentrated, and purified by column chromatography. The desired product 3bd (77%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (Bromomethyl)cyclopentane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; East China Normal University; Jiang Xuefeng; Meng Yingying; Wang Ming; (40 pag.)CN110563619; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary