Reference of 460-00-4,Some common heterocyclic compound, 460-00-4, name is 1-Bromo-4-fluorobenzene, molecular formula is C6H4BrF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
30 g (0.26 mol) of indole in a 250 mL round bottom flaskAnd 44.8 g (0.26 mol) of 4-fluorobromobenzene,Potassium fluorine 29.8 g (0.51 mol),1.35 g (5 mmol) of 18-crown-6 and 300 ml of dimethyl sulfoxide were added and refluxed for 24 hours.After the reaction was completed, the reaction mixture was cooled to room temperature, extracted, and the organic layer was concentrated under reduced pressure, separated by column chromatography using hexane and ethyl acetate, and dried to obtain 47.6 g (68.3%) of the compound represented by Chemical Formula 11-a.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-fluorobenzene, its application will become more common.
Reference:
Patent; SFC Ltd.; Che Jong-tae; Jeong Seong-uk; Park Ji-hui; Ryu Yeon-gwon; (47 pag.)KR101996648; (2019); B1;,
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