Reference of 21524-34-5, A common heterocyclic compound, 21524-34-5, name is 2-Bromo-1,3,5-triisopropylbenzene, molecular formula is C15H23Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 2-bromo-1,3,5-triisopropylbenzene (60.1 mg, 212 mumol), Bu3SnH (68.3 muL, 254 mumol), and V-65 (10.5 mg, 42.3 mumol) in THF-d8 (6 mL) was stirred at reflux for 3 h. The mixture was concentrated in vacuo, and the residue was purified by column chromatography on silica gel (hexane) to give 2-deutero-1,3,5-triisopropylbenzene (42.9 mg, 98%). 1H NMR (270 MHz): 1.17 and 1.20 (each as s, 18H, CH3), 2.77-2.88 (m, 3H, CH), 6.89 (s, 2.83H, 2-H, 4-H, 6-H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Mutsumi, Tomonobu; Iwata, Hiroki; Maruhashi, Kazuo; Monguchi, Yasunari; Sajiki, Hironao; Tetrahedron; vol. 67; 6; (2011); p. 1158 – 1165;,
Bromide – Wikipedia,
bromide – Wiktionary