Application of 4549-33-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4549-33-1 as follows.
DIEA (259 mg, 2 mmol) and 1,9-dibromoctane (286 mg,1 mmol) were added to the mixture whichincluded compound 1a (508 mg, 2 mmol) in toluene/ethanol (EtOH) (1:1) (60 mL), followed by refluxfor 48 h. The solvent was removed under vacuum. The process of this reaction was controlled byLC-MS and TLC. For TLC control and purification, the DCM/MeOH (7/1) system was used. Neutralalumina oxide was used to purify the product (yield 50%). LC-MS: [M + H]+ = 633. 1H NMR (500 MHz, MeOD): delta = 1.31(m, 2H, CH2), 1.41 (m, 12H, 6xCH2), 2.20 (m, 4H, 2xCH2),3.04 (m, 4H, 2xNHCH2), 3.13 (m, 4H, 2xNHCH2), 3.89 (d, J = 10.3 Hz, 4H, 2xNCH2) 7.86 (t, J = 7.8 Hz,4H, ArH), 8.41 (d, J = 8.1 Hz, 4H, ArH), 8.60 (d, J = 7.1 Hz, 4H, ArH) ppm.13C NMR (125 MHz, CDCl3): delta = 22.3 (CH2), 23,2 (CH2), 26,5 (CH2), 27,1 (CH2), 28.7 (CH2),37.9 (CH2), 46.5 (CH2), 48,6 (CH2), 122.3 (Caro), 127.2 (CaroH), 127.3 (Caro), 130.7 (CaroH), 131.3 (Caro),134.3 (CaroH), 163.5 (C=O) ppm.
According to the analysis of related databases, 4549-33-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Keskin, Elif; Ucisik, Mehmet Hikmet; Sucu, Bilgesu Onur; Guzel, Mustafa; Molecules; vol. 24; 24; (2019);,
Bromide – Wikipedia,
bromide – Wiktionary