Share a compound : 10485-09-3

The synthetic route of 10485-09-3 has been constantly updated, and we look forward to future research findings.

10485-09-3, name is 2-Bromoindene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 10485-09-3

Under an argon atmosphere, a solution of zinc chloride g, 28.0 mmol) in tetrahydrofuran suspension (5 mL) was added with a solution of isopropyl magnesium bromide in tetrahydrofuran (0.78 M, 30.7 mL) at 0 C., and the resultant was stirred at the same temperature for 1 hour. Then a solution of tetrakistriphenyl phosphine palladium (800 mg, 0.70 mmol) and 2-bromoindene (3.87 g, 20.0 mmol) in tetrahydrofuran (10 mL) was added thereto, and the resultant was further stirred at the same temperature for 16 hours. The reaction solution was added with a saturated aqueous solution of ammonium chloride, and extracted with diethyl ether. The organic layer was dried over anhydrous sodium sulfate, concentrated in vacuo, and the resultant residue was purified using silica-gel chromatography (hexane). 2-Isopropylindene (2.25 g, 71.1%) was obtained as a colorless oil.1H-NMR (400 MHz, CDCl3) delta; 1.22 (d, J=6.6 Hz, 6H), 2.77 (septet, J=6.6 Hz, 1H), 3.30 (s, 2H), 6.50 (s, 1H), 7.10-7.34 (m, 4H).

The synthetic route of 10485-09-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KOWA COMPANY, LTD.; US2010/22572; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary