Adding a certain compound to certain chemical reactions, such as: 21120-91-2, name is 7-Bromobicyclo[4.2.0]octa-1,3,5-triene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 21120-91-2, SDS of cas: 21120-91-2
To a solution of Formula 5 chemical (3.69g,5mmol) in 50mL dry DMF was added NaH(432mg,18mmol), the mixture was stirred at room temperature for 1h. And 7-bromobicyclo[4.2.0]octa-1,3,5-triene(Br-BCB)(2.75g,15mmol) was added to above solution via syringe. The mixture was heated to 60C and stirred overnight. After quenched with water, the mixture was poured into water to remove DMF. The residue was filtrated and the resulting solid was dissolved with dichloromethane, which was then washed with water. The solvent was removed under vacuum and the residue was extracted with dichloromethane. The product was then obtained by column chromatography on silica gel (65%yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-Bromobicyclo[4.2.0]octa-1,3,5-triene, and friends who are interested can also refer to it.
Reference:
Patent; ROHM AND HAAS ELECTRONIC MATERIALS LLC; DOW GLOBAL TECHNOLOGIES LLC; SPENCER, LIAM; LIU, CHUN; ZHU, MINRONG; MCDOUGAL, NOLAN T; FENG, SHAOGUANG; TREFONAS, PETER; DEVORE, DAVID D; TANG, ZHENGMING; FENG, JICHANG; SOKOLOV, ANATOLIY; (41 pag.)TW2016/25529; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary