Synthetic Route of 64248-56-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 64248-56-2 name is 2-Bromo-1,3-difluorobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 2, 6-difluorobromobenzene (125.5 g, 650 mmol) in 98% sulphuric acid (250 ml) was cooled in an ice-water bath and then treated with a 1: 1 mixture of 98% sulphuric acid and fuming nitric acid (100 ml) added at such a rate that the internal temperature never exceeded 35C. Once addition was complete the reaction was stirred at ambient temperature for 3 h then poured onto ice. This mixture was diluted with water (final volume 5 1), the resulting solid collected by filtration, washed with water, then dried under vacuum over phosphorus pentoxide, to afford 2-bromo-1, 3-difluoro-4-nitrobenzene as a cream-coloured solid (145 g, 94%) : 1H NMR (360 MHz, CDCl3) 8 7.10-7. 15 (1H, m), 8.09-8. 16 (1H, m).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-1,3-difluorobenzene, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2003/93272; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary