Electric Literature of 58534-95-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 58534-95-5 as follows.
3-Bromo-2-fluoroaniline (10 g, 52.63 mmol) was dissolved in DCM (100 mL) under nitrogen atmosphere. Dry pyridine was added (6 mL, 73.68 mmol), followed by 2,5-difluorobenzenesulfonyl chloride (7.08 mL, 52.63 mmol) and the mixture was stirred at r.t. for 2 h. It was then diluted with DCM and washed with aqueous 0.5 N HCI (3 x 80 mL) and brine. The organic layer was dried over Na2S04 and evaporated to dryness. The solid was taken up with diethyl ether and stirred for 30 min. It was then filtered and dried at 40C under reduced pressure to give 17.8 g of A/-(3-bromo-2- fluoro-phenyl)-2,5-difluoro-benzenesulfonamide as a pale yellow solid (92%).HPLC: Rt: 6.28 min1H NMR (401 MHz, DMSO-d6) delta ppm 10.86 (s, 1 H), 7.50 – 7.73 (m, 4 H), 7.23 – 7.31 (m, 1 H), 7.12 (dt, J = 1.3, 8.1 Hz, 1 H)
According to the analysis of related databases, 58534-95-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NERVIANO MEDICAL SCIENCES S.r.l.; PULICI, Maurizio; TRAQUANDI, Gabriella; MARCHIONNI, Chiara; SCOLARO, Alessandra; COLOMBO, Nicoletta; WO2012/113774; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary