Electric Literature of 13633-25-5,Some common heterocyclic compound, 13633-25-5, name is 1-Bromo-4-phenylbutane, molecular formula is C10H13Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
lambda/-{2-r(3-phenylbutoxyphenylVphenyl- aminolethvDacetamide (5i): A mixture of lambda/-(3-hydroxyphenyl)aniline (2.7 mmol) and 1-bromo-4-phenylbutane (2.02 mmol) was refluxed for 5 h in a 10% ethanol solution of KOH. The reaction mixture was cooled to room temperature, poured into water and extracted three times with EtOAc. The combined organic phases were washed with brine, dried (Na2SO4) and evaporated under reduced pressure to provide a residue which was purified by flash chromatography (silica gel; cyclohexane/EtOAc, 8:2 as eluent). Yield lambda/-(3-phenylbutoxyphenyl)-aniline (3i): 86%; oil; EI-MS 317 (M+), 91 (100); 1H-NMR (CDCI3): delta 1.83 (m, 4H), 2.68 (m,
The synthetic route of 13633-25-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MCGILL UNIVERSITY; UNIVERSITA DEGLI STUDI DI PARMA; UNIVERSITA DEGLI STUDI DI MILANO; UNIVERSITA DEGLI STUDI DI URBINO; WO2007/79593; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary