Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 327-52-6, name is 1-Bromo-2,4,5-trifluorobenzene, A new synthetic method of this compound is introduced below., name: 1-Bromo-2,4,5-trifluorobenzene
Example 7: Preparation of (R)-benzyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihvdro- ri ,2,41triazolor4,3-aipyrazin-7(8H)-yl)-1 -(2,4,5-trifluorophenyl)butan-2- ylcarbamateA solution of 1 -bromo-2,4,5-trifluorobenzene (638 mg, 3.02 mmol) in THF (5 ml_) was slowly added to a suspension of magnesium turnings (73 mg, 3.02 mmol) in THF (5 ml_). The mixture was allowed to stir for 1 hour at 50 0C. To a solution of (S)-benzyl 1 -iodo-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro- [1 ,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-2-ylcarbamate (406 mg, 0.76 mmol) in THF (5ml_) at -20 0C, cuprous bromide methylsulfide complex (311 mg, 1.51 mmol) was added. The organomagnesium bromide solution was added dropwise and the mixture was allowed to warm up to room temperature. Once de reaction was completed, NH4CI saturated solution (20 ml_) and AcOEt (20 ml_) were added sequentially. The organic layer was dried with anhydrous Na2SO4, filtered and concentrated. Digestion in toluene:heptane (5:1 ) leads to the precipitation of (R)-benzyl 4-oxo-4-(3- (trifluoromethyl)-5,6-dihydro-[1 ,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1 -(2,4,5- trifluorophenyl)butan-2-ylcarbamate (221 mg, 54% yield).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ESTEVE QUIMICA, S.A.; BARTRA SANMARTI, Marti; RUSTULLET OLIVER, Albert; FERNANDEZ HERNANDEZ, Sara; MONSALVATJE LLAGOSTERA, Montserrat; WO2010/97420; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary