In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 129316-09-2 as follows. name: 1,3-Dibromo-5-(tert-butyl)benzene
Step 1 1-Bromo-3-(tert-butyl)-5-methoxybenzene (14a) To a solution of 1,3-dibromo-5-tert-butylbenzene (289 mg, 1 mmol) in 20 mL DMF were added NaOMe (2 eq) and Cul (0.03 eq). The mixture was stirred at 80C for 3 h and then was poured into water and extracted with EA. The organic layers were washed with brine and dried over anhydrous Na2SO4. After filtration, the filtrate was evaporated to give compound 14a as solid (200 mg, 82%).
According to the analysis of related databases, 129316-09-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Phenex Pharmaceuticals AG; EP2511263; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary