Electric Literature of 615-54-3, These common heterocyclic compound, 615-54-3, name is 1,2,4-Tribromobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[00149] A suspension of compound 1 (27.0 g, 85.7mmol), potassium vinyltrifluoroborate (compound 4) (41.4 g, 0.31 mol), PdCI2 (0.76g, 4.3mmol), Cs2C03 (125.6 g, 0.39 mol) and PPh3 (3.38g, 12.9mmol) in a mixture of THF and water (400ml_, THF/H20 9:1 ) was heated at reflux for 17h under a nitrogen atmosphere. The reaction was cooled to room temperature and the solvent removed by evaporation. The residue obtained was diluted with water (300ml_) and extracted with ethyl acetate (100ml_ x 3). The combined organic extracts were washed with water (200mL) and brine (100ml_), dried (Na2S04) and concentrated to give the crude product, which was purified by column chromatography (neat petroleum ether), illustrated below, to afford compound 5 (1 1.40g, 85%) as an oil.
The synthetic route of 615-54-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOULOS & COOPER PHARMACEUTICALS PTY LTD; BOULOS, Ramiz; FEUTRILL, John; (105 pag.)WO2017/27933; (2017); A1;,
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bromide – Wiktionary