7051-34-5, name is (Bromomethyl)cyclopropane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 7051-34-5
Step 1: Synthesis of 4-(benzyloxy)-3-(cyclopropylmethoxy)benzaldehyde (119) 4-(benzyloxy)-3-hydroxybenzaldehyde (640 mg, 2.8 mmol) was dissolved in DMF (5 ml), then K2CO3 (774 mg, 5.6 mmol) and (bromomethyl)cyclopropane (544 mul, 5.6 mmol) were added, and the mixture was stirred at 90 C. for 2 hours. The reaction was diluted with Et2O and the organic phase was washed with NaHCO3 sat sol, water and brine, dried over Na2SO4 and evaporated under vacuum to give 750 mg of the desired product (yield 95%).
The synthetic route of 7051-34-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CHIESI FARMACEUTICI S.p.A.; ARMANI, Elisabetta; Amari, Gabriele; Esposito, Oriana; Carzaniga, Laura; Capaldi, Carmelida; US2014/155391; (2014); A1;,
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