Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2606-51-1, name is 5-(Bromomethyl)benzo[d][1,3]dioxole, A new synthetic method of this compound is introduced below., Safety of 5-(Bromomethyl)benzo[d][1,3]dioxole
General procedure: A 10-mL round-bottom flask was equipped with a magnetic stir bar and a reflux condenser. Then 0.4 mmol of alkyl halide and 0.44 mmol of sodium azide were added to 1.5 mL of anhydrous dimethylformamide. The reaction mixture was stirred at 60 C for 2 h under nitrogen atmosphere. After cooling to room temperature, TLC indicated the disappearance of the starting material. 0.44 mmol of active ketone and 0.44 mmol of DBU were then added to the reaction mixture, which was stirred for 3 h at 60 C. Brine (40 mL) was added to the reaction mixture and washed with EtOAc (3 10 mL). The organic layer was dried (Na2SO4) and the solvent evaporated under reduced pressure. Flash column chromatography afforded the pure triazole.
The synthetic route of 2606-51-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Gonzalez-Calderon, Davir; Aguirre-De Paz, Jose G.; Gonzalez-Gonzalez, Carlos A.; Fuentes-Benites, Aydee; Gonzalez-Romero, Carlos; Tetrahedron Letters; vol. 56; 13; (2015); p. 1713 – 1715;,
Bromide – Wikipedia,
bromide – Wiktionary