Synthetic Route of 4549-33-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4549-33-1, name is 1,9-Dibromononane, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 6-(4-chlorophenyl)-1-methyl-8-(1H-pyrazol-4- yl)spiro[benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine-4,1′-cyclopropane] (59-2) (100 mg, 249 mumol) in DMF(1.5 mL) was added Cs2CO3 (121 mg, 373 mumol) and 1,9-dibromononane (85.2 mg, 298 mumol) . The mixture was stirred for 4h at 30 C. Water(30 mL) and EA(30 mL*2) were added. The Combined organic layers was dried over Na2SO4 and concentrated, purified with prep- TLC (EA=100%) to give 8-(1-(9-bromononyl)-1H-pyrazol-4-yl)-6-(4-chlorophenyl)-1- methylspiro[benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine-4,1′-cyclopropane] (113-1) (39.2 mg, 26.1 %) as an oil. LCMS (ES+): m/z= 605 [M + H]+
The chemical industry reduces the impact on the environment during synthesis 1,9-Dibromononane. I believe this compound will play a more active role in future production and life.
Reference:
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; FITZGERALD, Mark, E.; MICHAEL, Ryan, E.; (790 pag.)WO2017/197056; (2017); A1;,
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