Synthetic Route of 4549-33-1, A common heterocyclic compound, 4549-33-1, name is 1,9-Dibromononane, molecular formula is C9H18Br2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Synthesis of Compound 9.1 [0189] To a solution of 2075-45-8 (1.30 g, 8.84 mmol, 1.0 eq) in CH3CN (20 ml) were added K2C03 (1.41 g, 13.26 mmol, 1.5 eq) and 4549-33-1 (5.05 g, 7.68 mmol, 2.0 eq). The reaction mixture was stirred at 65 C for 16 h. After cooling down to ambient temperature, the resulting solution was diluted with H20 (100 mL), extracted with ethyl acetate (100 ml). The organic layer was dried over anhydrous sodium sulphate and concentrated in vacuo. The residue was purified by silica gel column (PE / EA = 10 / 1) to give 9.1 (2.08 g, yield: 66%) as a white solid. 1H NMR (400 MHz, CDC13) delta: 7.44 (s, 1H), 7.38 (s, 1H), 4.09 (t, J = 1.2 Hz, 2H), 3.41 (t, J = 1.2 Hz, 2H), 1.87-1.80 (m, 4H), 1.42-1.37 (m, 2H), 1.29-1.24 (m, 8H); ESI-MS (M+H) +: 351.0.
The synthetic route of 4549-33-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIOGEN IDEC MA INC.; JENKINS, Tracy; VESSELS, Jeffery; WO2014/143672; (2014); A1;,
Bromide – Wikipedia,
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