Some common heterocyclic compound, 766-46-1, name is 2′-Bromophenylacetylene, molecular formula is C8H5Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C8H5Br
[Example 2] The following will describe other synthetic examples based on reaction formula (VI) below. First, a method of synthesis from 1,4-bis[(2-bromophenyl)ethynyl]-2,5-dibromobenzene (6) as a raw material will be described. A 3/1 toluene/triethylamine (9 mL) solution of 2-bromo-1-ethynylbenzene (90 mg, 4.98 mmol) was added to a mixed 3/1 toluene/triethylamine (12 mL) solution of 1,4-dibromo-2,5-diiodobenzene (1.15 g, 2.35 mmol), dichlorobis(triphenylphosphine) palladium (II) (33 mg, 47 mmol), and copper iodide (18 mg, 95 mmol) at room temperature and stirred for 12 hours at room temperature. A 1N aqueous solution of hydrochloric acid was added to the reaction mixture. The mixture was then subjected to extraction using methylene chloride. The obtained organic layer was washed in a saturated saline solution and dried with anhydrous magnesium sulfate. After removing the drying agent by filtering, the filtered solution was concentrated under reduced pressure. The resultant mixture was recrystallized from benzene, to obtain 1.17 g (1.97 mmol) of the target product 6 in the form of a white solid at a yield of 84%. 1H NMR (CDCl3): delta 7.20-7.35 (m, 4H), 7.59-7.65 (m, 4H), 7.83 (s, 2H). 13C NMR (CDCl3): delta 90.81, 95.00, 123.57, 124.47, 125.59, 126.40, 127.02, 130.15, 132.54, 133.66, 136.34. Anal. Calcd for C22H10Br4: C, 44.49; H, 1.70. Found: C, 44.42; H, 1.54.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 766-46-1, its application will become more common.
Reference:
Patent; Japan Science and Technology Agency; EP1548019; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary