Synthetic Route of 3344-70-5, The chemical industry reduces the impact on the environment during synthesis 3344-70-5, name is 1,12-Dibromododecane, I believe this compound will play a more active role in future production and life.
General procedure: A suspension of lithium acetylide ethylenediamine complex (247 mg, 2.70 mmol) in dry DMSO (4 mL) was stirred for 10 min at room temperature under nitrogen. After the mixture was cooled to 8 °C, 1-bromo-7-hexadecyne (708 mg, 2.35 mmol) was added dropwise. The reaction mixture was stirred at rt overnight and cooled to 0 °C. Water (1 mL) was added very slowly. The suspension was stirred for 10 min at rt, then poured into water (60 mL), and extracted with hexane. The combined organic phases were dried (Na2SO4), filtered, evaporated to dryness under reduced pressure, and purified by chromatography (elution with hexane) to give Yield 66percent: 1H NMR delta 1.25 (12H, m, (CH2)6); 1.36 (4H, m, CH2C-C-C?C); 1.49 (4H, m, CH2C-C?C); 1.91 (1H, t, J = 2.6 Hz, C?CH); 2.16 (4H, td, J = 2.6 Hz, J = 7.2 Hz, CH2-C?C); 13C NMR delta 18.4 (C-3 and 14), 28.5 (C-4 and 13), 28.7 (C-5 and 12), 29.1 (C-6 and 11), 29.5 and 29.6 (C-8, 9, 10 and 11), 68.0 (C-1 and 16), 84.8 (C-2 and 15).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,12-Dibromododecane, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Vilchze, Catherine; Leung, Lawrence W.; Bittman, Robert; Jacobs, William R.; Chemistry and Physics of Lipids; vol. 194; (2016); p. 125 – 138;,
Bromide – Wikipedia,
bromide – Wiktionary