Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5003-71-4, name is 3-Bromopropan-1-amine hydrobromide, A new synthetic method of this compound is introduced below., Product Details of 5003-71-4
Di-tert-butyl dicarbonate (1.01 g, 4.6mmol) was dissolved in N,N-dimethylacetamide (12ml) and added with 3-bromoaminopropane hydrobromide (1.01 g, 4.6mmol) and potassium carbonate(0.64 g, 4.6mmol). The reaction was carried out at 45-50C for 1 hour. 2-(5-Nitropyridine-2-yl)phenol(0.50 g, 2.3mmol) synthesized in Example 63 (i) and potassium carbonate (0.64 g, 4.6mmol) were added. The reaction was carried out at 50C for 20 minutes and at 75-80C for 1 hour. The reaction was cooled and extracted with addition of water and ethyl acetate. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The precipitated crystals were filtered with addition of water. The resulting crystals were dissolved in methanol, and hydrolyzed with dropwise addition of hydrochloric acid at 50C. The solution was concentrated and neutralized with saturated aqueous sodium bicarbonate. The precipitated crystals were filtered to give the title compound (0.57 g, 66.4%).
The synthetic route of 5003-71-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Daito Chemix Corporation; Kyoto University; KAKIZUKA, Akira; HORI, Seiji; SHUDO, Toshiyuki; FUCHIGAMI, Tomohiro; EP2599771; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary