Adding a certain compound to certain chemical reactions, such as: 960203-41-2, name is (2-Bromophenyl)(2,4-dimethylphenyl)sulfane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 960203-41-2, HPLC of Formula: C14H13BrS
In a 200 ml reaction flask,Compound 6 (5.8 g, 20 mmol) was added,Piperazine (2.1 g, 24 mmol),N-diisopropylethylamine (DIEA) (5.17 g) and 75 ml of DMF,Stirring to dissolve,Another cuprous iodide (0.4 g) was added,The reaction was carried out at 80 ° C for 10 hours,After completion of the reaction, the temperature was lowered to room temperature,The reaction solution was concentrated,And extracted three times with dichloromethane / water (V: V)The aqueous layer was washed once with dichloromethane,The combined organic phases were dried over anhydrous sodium sulphate,And concentrated to obtain 5.0 g of the compound (7) in a yield of 84.6percent
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Reference:
Patent; Shandong Kangmeile Pharmaceutical Technology Co., Ltd.; Geng, Fengluan; Fan, Mingwei; Liu, Yunfeng; Yuan, Zengfei; Liu, Xiaojun; (8 pag.)CN105985301; (2016); A;,
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