Synthetic Route of 61326-44-1, A common heterocyclic compound, 61326-44-1, name is 1,1,2,2-Tetrakis(4-bromophenyl)ethene, molecular formula is C26H16Br4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under the protection of high purity nitrogen,In the 50ml schleckThe reaction flask was charged with 15 ml of tetrakis (4-bromophenyl) ethane (648 mg, 1 Ommol, 1. eqq), Pd (PPh3) 4 (116 mg, 0 lmmol, 0 leq) and re-distilled toluene After dissolving, 3 ml of an ethanol solution dissolved in 4-methoxyphenylphenylborate borane (1170 mg, 5 O Ommol, 5 Oeq) and 1 ml of an aqueous solution of 2MNa2C03 were added to the reaction flask by means of a syringe, and the reaction solution was heated to 50 to 70 C was refluxed for 12 h, cooled to room temperature, extracted with dichloromethane / water. The combined organic layers were dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure and recrystallized from ethanol to give 545 mg of a white solid in 72percent yield.
The synthetic route of 61326-44-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY, CHINESE ACADEMY OF SCIENCES; LI YI, LI YI; HAO, QINGSHAN; CHEN, JINPING; ZENG, YI; YU, TIANJUN; (14 pag.)CN104557552; (2016); B;,
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