Electric Literature of 1195-33-1,Some common heterocyclic compound, 1195-33-1, name is 4-Bromobenzenesulfinic acid, molecular formula is C6H5BrO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To an oven-dried 3-neck round-bottom flask (10 mL) equipped with a stir bar were added the olefin (0.50 mmol), sulfinic acid (1.25 mmol), nBu4NBF4 (82.3 mg, 0.25 mmol), and acetonitrile (10 mL). The flask was equipped with a platinum electrode (1.0 cm ×1.0 cm × 0.3 mm) and a graphite rod electrode. The reaction mixture was stirred and electrolyzed at a constant current (10 mA) at room temperature for 4.5 h. Next, the reaction mixture was concentrated, and the residue was purified by silica gel chromatography to afford the pure product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromobenzenesulfinic acid, its application will become more common.
Reference:
Article; Zhang, Zhefan; Yan; Ma, Dengke; Sun, Jianwei; Chinese Chemical Letters; vol. 30; 8; (2019); p. 1509 – 1511;,
Bromide – Wikipedia,
bromide – Wiktionary