22034-13-5, name is 4-Bromobenzo[c][1,2,5]thiadiazole, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 22034-13-5
To a flask equipped with a reflux device, 3.3 g (29.0 mmol) of t-butoxypotassium, 0.3 g (0.5 mmol) of PEPPSI?-IPr (manufactured by Sigma-Aldrick corporation, product name) as a Pd catalyst, 150 mL of toluene, 5.2 g (24.1 mmol) of the compound (b), and 8.0 mL (26.5 mmol) of bis(2-ethylhexyl)amine were added, and it was refluxed at 120° C. for five hours under a nitrogen atmosphere. After a reaction was finished, solids in a reaction solution were removed by filtration, the filtrate was condensed, and then refinement was performed by column chromatography using hexane/ethyl acetate (99:1, volume ratio) as a developing solution, to thereby obtain a compound (c) (5.3 g, 14 mmol, yield: 58percent).
The synthetic route of 22034-13-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AGC Inc.; MIYAKE, Noriaki; Okada, Satoshi; Irisawa, Jun; Konishi, Teppei; Matsuura, Keigo; US2018/346729; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary