Electric Literature of 66417-30-9, The chemical industry reduces the impact on the environment during synthesis 66417-30-9, name is 2-Bromo-1-methyl-4-(trifluoromethyl)benzene, I believe this compound will play a more active role in future production and life.
[00155] A mixture of 2-bromo-4-trifluoromethyl toluene (1 equivalent), n- butyl vinyl ether (5 equivalents), palladium acetate (0.1 equivalents), DPPP (0.22 equivalents), K2CO3 (1.2 equivalents), and DMF-H20 (0.3 M to bromide) was stirred under N2 for 18 hours at 100C. The reaction mixture was then cooled to room temperature and hydrolyzed with 5% HCI for 30 min. Extraction with EtOAc, washing with H20, sat aq. NaCi, drying (MGS04), and concentration gave an oil. Purification of the crude material by silica gel flash chromatography using an 0% hexanes to 50% HEXANES-ETOAC gradient gave 2′-methyl-5′- trifluoromethylacetophenone : the compound prepared showed a molecular ion M-= 201. 1.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-methyl-4-(trifluoromethyl)benzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CYTOKINETICS, INC.; WO2005/5382; (2005); A2;,
Bromide – Wikipedia,
bromide – Wiktionary