Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 38573-88-5, name is 1-Bromo-2,3-difluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 38573-88-5
To a solution of Intermediate 37b (20.00 mg, 38.56 muiotaetaomicron) and l-bromo-2,3-difluoro- benzene (22.33 mg, 115.68 muiotaetaomicron, 12.98 pL) in CH3CN (500 pL) was added Cs2C03 (50.25 mg, 154.24 muiotaetaomicron) and XPhos Pd G3 (3.26 mg, 3.86 muiotaetaomicron). After stirring under N2 atmosphere at 70C for one hour, the reaction mixture was purified by prep-TLC (DCM: MeOH = 10: 1) to give the Intermediate 38b (15.00 mg, 23.78 muiotaetaomicron, 61.68% yield) as a yellow oil.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 38573-88-5.
Reference:
Patent; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; COMER, Eamon; KATO, Nobutaka; MORNINGSTAR, Marshall; MELILLO, Bruno; (154 pag.)WO2018/175385; (2018); A1;,
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