1073-39-8, name is 3-Bromobicyclo[4.2.0]octa-1,3,5-triene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 3-Bromobicyclo[4.2.0]octa-1,3,5-triene
To a mixture of 3-bromobicyclo[4.2.0]octa-1,3,5-triene (1092.9 mg, 5.97 mmol) THF (4 mL) was added, cooled to -78 C and the flask was evacuated, re-filled with nitrogen. To the mixture was added 3.7 ml of n-BuLi (3.7 ml, 5.97 mmol, 1.6 M in hexane) dropwise with stirring at -78 C for 25 min. 4- (Benzyloxy)-5-bromo-2-methylbenzaldehyde (1.82 g, 5.97 mmol) in THF (6 mL) was then added to the solution and the mixture was kept stirring for 1 h at -78 C. The resulting mixture was quenched with aqueous NH4CI (15 ml), extracted with EtOAc three times (20 ml each time). The combined extracts were washed with brine, dried over Na2S04, filtered and concentrated. The residue was purified by flash column chromatography on silica gel (40 g, EtOAc/heptane: 0>10%) to yield (4-(benzyloxy)-5-bromo-2- methylphenyl)(bicyclo[4.2.0]octa-1 (6),2,4-trien-3-yl)methanol as a colorless oil. MS (ES) m/z: 431.10 [M+Na]+.
The synthetic route of 1073-39-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; GAUL, Micheal; KUO, Gee-Hong; XU, Guozhang; LIANG, Yin; (218 pag.)WO2018/89449; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary