Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 112734-22-2, name is (4-Bromo-2-fluorophenyl)methanamine, A new synthetic method of this compound is introduced below., Quality Control of (4-Bromo-2-fluorophenyl)methanamine
At 0C, p-toluenesulfonyl chloride (4.00g, 21mmol) was added in portion to a solution of 5-bromo-2-fluorobenzlamine (4.08g, 20mmol) and triethylamine (4.04g, 40mmol) in DCM (60mL). The mixture was reacted at 0C for 30mins, followed by removing the ice bath, further reacting at room temperature for 16hrs, then being concentrated under reduced pressure. The residue was purified by silica column chromatography (PE:EA = 5:1) to give compound 9-f (5.30g, yield 74%). LC-MS (ESI): m/z = 358 [M+H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shanghai Yingli Pharmaceutical Co. Ltd.; XU, Zusheng; ZHANG, Nong; SUN, Qingrui; WU, Tianzhi; (104 pag.)EP3275867; (2018); A1;,
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