Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 656-64-4, name is 3-Bromo-4-fluoroaniline, A new synthetic method of this compound is introduced below., Safety of 3-Bromo-4-fluoroaniline
A solution of sodium nitrite (4.2 g , 60 mmol) was added drop-wise to a mixture of 3-bromo-4-fluoroaniline (11.2 g, 58.9 mmol) and concentrated HCl (30 mL, 0.36 M) at 0 0C over 30 min. The resulting clear solution was stirred for 45 min, and a solution of SnCl2*2H2O (27 g, 120 mmol) in concentrated HCl (30 mL) was added drop-wise at 0 0C over 1.5 h. The mixture was stirred for 18 h at room temperature. The resulting precipitate was collected by filtration and crystallized from ethanol to provide the title compound (6.2 g, 42 %) as a yellow powder: 1H NMR (300 MHz, DMSO-J6) delta 10.24 (s, 3H), 8.42 (s, IH), 7.36-7.30 (m, 2H), 7.03-6.98 (m, IH).
The synthetic route of 656-64-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ALBANY MOLECULAR RESEARCH, INC.; WO2009/89482; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary