Adding a certain compound to certain chemical reactions, such as: 43204-63-3, name is Bis(2-Bromoethyl)amine hydrobromide, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 43204-63-3, Safety of Bis(2-Bromoethyl)amine hydrobromide
a Synthesis of 2-bromo-N-(2-bromoethyl)-N-carbobenzoxyethanamine (1c): Benzyl chloroformate (1.97 ml, 13.8 mmol) and 1M sodium hydroxide solution is added with vigorous stirring to an ice-cold solution of bis(2-bromoethyl)amine hydrobromide (4.5 g, 14.4 mmol) in water (25 ml) until the pH is just basic (about 24 ml). The mixture is acidified with 1M hydrochloric acid (2 ml) and extracted with ether (3*40 ml). The organic phase is washed with sodium hydrogen carbonate solution and water, dried over magnesium sulfate and concentrated, and the residue is chromatographed (hexane/ethyl acetate 5:1?4:1). Compound 1 c (4.1 g, 81%) is obtained. 1 H-NMR (300 MHz, CDCl3): delta=3.43, 3.53 ?2 m, 4H, N(CH2 –CH2 Br)2!, 3.73 ?m, 4H, N(CH2 –CH2 Br)2!, 5.17 (s, 2H, CH2 Ph), 7.36 (m, 5H, Ph).
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Reference:
Patent; Hoechst Aktiengesellschaft; US5739300; (1998); A;,
Bromide – Wikipedia,
bromide – Wiktionary