Related Products of 2606-51-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2606-51-1, name is 5-(Bromomethyl)benzo[d][1,3]dioxole, This compound has unique chemical properties. The synthetic route is as follows.
To a suspension of 6-methyl-3-(tetrahydro-2H-pyran-4-yl)imidazo[1 ,5-a]pyrazin-8(7/-/)-one (100 mg, 429 mol) in dry DMF (2 mL) was added Cs2C03 (279 mg, 858 Mmol) and 5- (bromomethyl)benzo[d][1 ,3]dioxole (138 mg, 643 imol). The mixture was bubbled with 2 for 2 min and heated at 60C for 16 hours. The mixture was concentrated. DCM (30 mL) was added to the residue. It was filtered and the filter cake was washed with DCM (20 mL). The filtrate was concentrated and purified by flash chromatography on silica gel (10%~100% ethyl acetate in petroleum ether) to give 7-(benzo[d][1 ,3]dioxol-5-ylmethyl)-6-methyl-3- (tetrahydro-2H-pyran-4-yl)imidazo[1 ,5-a]pyrazin-8(7/-/)-one (81.74 mg, 52% yield). (1018) 1H NMR (CDCIa 400 MHz): delta 7.92 (s, 1 H), 6.76 – 6.69 (m, 4H), 5.95 – 5.93 (m, 2H), 5.13 (s, 2H), 4.14 – 4.11 (m, 2H), 3.61 – 3.55 (m, 2H), 3.10 – 3.05 (m, 1 H), 2.21 (s, 3H), 2.20 – 2.10 (m, 2H), 1.90 – 1.86 (m, 2H). (1019) LC-MS: fR = 2.245 min (method 3), m/z = 368.2 [M + H]+.
The chemical industry reduces the impact on the environment during synthesis 5-(Bromomethyl)benzo[d][1,3]dioxole. I believe this compound will play a more active role in future production and life.
Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars, Kyhn; LANGGARD, Morten; JESSING, Mikkel; VITAL, Paulo, Jorge, Vieira; JUHL, Karsten; (159 pag.)WO2018/78042; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary