Application of 2635-13-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2635-13-4 name is 5-Bromobenzo[d][1,3]dioxole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A heavy-walled tube was charged with 5.01 grams (3 ml, 24.896 mmol) ofcommercially available 5-bromo-1,3-benzodioxole followed by dry DMF (5ml) followed by copper iodide (0.474 grams, 2.490 mmol, 0.10 equivalents), PdCl2(PPh3)2 (0.349 grams, 0.4979 mmol, 0.02 equivalents), and triethylamine (35 ml) and then subjected tooxygen removal using a freeze-pump-thaw method. Finally TMS-acetylene (3.68 grams, 5.3 ml,37.34 mmol) was then added and the tube was quickly sealed and heated in an oil bath at 90 Cfor 24 hours. At this time the reaction was cooled and worked up by concentration in vacuo andsubmitted to flash chromatography using straight hexanes to afford compound weighing 3.4 g.Yield is 62 %.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromobenzo[d][1,3]dioxole, and friends who are interested can also refer to it.
Reference:
Article; Abrams, Jason N.; Zhao, Qi; Ghiviriga, Ion; Minaruzzaman; Tetrahedron; vol. 68; 2; (2012); p. 423 – 428;,
Bromide – Wikipedia,
bromide – Wiktionary