These common heterocyclic compound, 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1,4-Dibromo-2,5-difluorobenzene
Under a nitrogen atmosphere, 200 ml Schlenk reaction vessel, 1, 4 – dibromo – 2, 5 – difluorobenzene (wako pure medicine industry) was added 80 ml (22.0mmol) (dehydration grade) and THF 5.98 g. The solution was cooled to 0 C, ethyl magnesium chloride (sigma-Aldrich -, 2.0M) 13.0 ml of the solution were dropped THF (26.0mmol). The mixture 10 minutes at 0 C aged. The resulting solution was added to copper (II) chloride (wako pure medicine industry) 3.89 g (29.0mmol), was stirred at room temperature for between 3. 40 ml water was added to stop the reaction container 1N hydrochloride. Extracted with toluene, the organic phase was washed with brine, dried over anhydrous sodium sulfate. Concentration under reduced pressure, the residue obtained by removing the low-boiling component from the eluent used 4, 4 ‘- dibromo – 2, 2′, 5, 5’ – 2.98 g (71% yield) of a pale yellow solid obtained tetra- fluoro biphenyl.
The synthetic route of 1,4-Dibromo-2,5-difluorobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TOSOH CORPORATION; MIYASHITA, MASATO; WATANABE, MASATO; (24 pag.)JP2017/160156; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary