Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2051-99-2, name is 1-Bromo-4-isobutylbenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Bromo-4-isobutylbenzene
A mixture of 5.0 g (23.5 mmol) of 1-bromo-4-isobutylbenzene, 3.14 g (26.7 mmol) of zinc cyanide, 963 mg (2.35 mmol) of dicyclohexyl-(2′,6′-dimethoxybiphenyl-2-yl)phosphane and 1.08 g (1.17 mmol) of tris(dibenzylidene-acetone)dipalladium in 230 ml of DMF/water (99:1) was heated at 120 C. under inert, oxygen-free conditions for 1 h. After cooling to RT, the mixture was diluted with approx. 1,000 ml of water and extracted three times with approx. 150 ml of ethyl acetate each time. The combined organic extracts were washed successively with water and saturated sodium chloride solution. After drying over anhydrous magnesium sulphate, the mixture was filtered and the filtrate was freed from the solvent on a rotary evaporator. The residue obtained was purified by means of filtration with suction over silica gel with cyclohexane/ethyl acetate 10:1 as the mobile phase. 3.04 g (81% of th.) of the title compound were obtained.1H-NMR (400 MHz, CDCl3, delta/ppm): 7.56 (d, 2H), 7.23 (d, 2H), 2.53 (d, 2H), 1.94-1.83 (m, 1H), 0.90 (d, 6H).GC/MS (method K, EIpos): Rt=4.05 min, m/z=159 [M]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2011/301122; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary