These common heterocyclic compound, 58971-11-2, name is 3-Bromophenethylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 3-Bromophenethylamine
General procedure: 4-[(Ethoxycarbonyl)amino]butanoic acid (12a, 700 mg, 4mmol) was dissolved in an hydrous dichloromethane (14 mL) under argon atmosphere. The solution was cooled to 0 C. Triethylamine (1.2 mL, 870 mg, 8.6 mmol) and 3-fluorophenethylamine (0.6 mL, 4.6 mmol) were added consecutively. Afterwards EDC-HCl (900 mg, 4.7 mmol)was added in one portion. Catalytic amount DMAP (30 mg)was added, the resulting mixture was stirred for 1 h at 0 C and then for 16 h at room temperature. The reaction mixture was diluted with dichloromethane (30 mL) and consecutively washed with 1M HCl, saturated NaHCO3 solution and water (20 mL of each). The combined extracts were dried (Na2SO4) and evaporated to give an oily residue.The crude product was crystallized from hexane
The synthetic route of 3-Bromophenethylamine has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ahamed, Muneer; Vermeulen, Koen; Schnekenburger, Michael; Moltzau, Lise Roman; Levy, Finn Olav; Marton, Janos; Froeyen, Mathy; Olberg, Dag Erlend; Diederich, Marc; Bormans, Guy; Letters in drug design and discovery; vol. 14; 7; (2017); p. 787 – 797;,
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bromide – Wiktionary