Electric Literature of 1003-98-1, A common heterocyclic compound, 1003-98-1, name is 2-Bromo-4-fluoroaniline, molecular formula is C6H5BrFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: o-Bromaniline (1a, 0.2 mmol), benzoyl chloride (2a, 1.2 eq), Cu NPs (1.3 mg, 10 mol%), 1,10-phen(4.0 mg, 10 mol%), K2CO3 (2.0 equiv), and 1.5 mL of MeCN were added into a 5-mL sealed tubeunder N2. The mixture was stirred at 90 for 1 hour. Then, the reaction was stopped, and the reactionmixture was purified by flash column chromatography on silica gel (hexanes/EtOAc 15:1). Compound4a was obtained in >99 % of yield.
The synthetic route of 1003-98-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wang, Yong; Wu, Chaolong; Nie, Shoujie; Xu, Dingjian; Yu, Min; Yao, Xiaoquan; Tetrahedron Letters; vol. 56; 49; (2015); p. 6827 – 6832;,
Bromide – Wikipedia,
bromide – Wiktionary