Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 22034-13-5, name is 4-Bromobenzo[c][1,2,5]thiadiazole, A new synthetic method of this compound is introduced below., Quality Control of 4-Bromobenzo[c][1,2,5]thiadiazole
After reacting lithium diisopropylamide (LDA) with N-Boc-3-methylindole in tetrahydrofuran (THF) at -20 ° C.,Triisopropyl borate was added and reacted for 1.5 hours to obtain N-Boc-3-methylindole-2-boronic acid.As shown by the following formula (8), “Boc” represents a tert-butoxycarbonyl group.Next, without isolating the obtained boronic acid, in the presence of tetrakis (triphenylphosphine) palladium (20 molpercent),The reaction was allowed to proceed at 95 ° C. for 4 hours in a mixed solvent of 4-bromo-2,1,3-benzothiadiazole and dioxane / potassium carbonate aqueous solution to obtain an indolylbenzothiadiazole derivative 1a in a yield of 84percent
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; YOKOHAMA NATIONAL UNIVERSITY; ITO, SUGURU; ASAMI, MASATOSHI; YAMADA, TAKESHI; TAGUCHI, TOMOHIRO; (23 pag.)JP2017/57191; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary