Synthetic Route of 1195-33-1, A common heterocyclic compound, 1195-33-1, name is 4-Bromobenzenesulfinic acid, molecular formula is C6H5BrO2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a mixture of alkynyliodine 1 (0.1 mmol), sulfinic acid 2 (0.2 mmol) in DME (2 mL) at room temperature under air. The reaction vessel was sealed and allowed to stir for 12 h at 100 C. After completion of the reaction, the resulting mixture was concentrated under vacuum and the residue was purified by flash column chromatography using a mixture of petroleum ether and ethyl acetate as eluent to give the desired products 3.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Wang, Leilei; Wei, Wei; Yang, Daoshan; Cui, Huanhuan; Yue, Huilan; Wang, Hua; Tetrahedron Letters; vol. 58; 51; (2017); p. 4799 – 4802;,
Bromide – Wikipedia,
bromide – Wiktionary