Sources of common compounds: 57946-63-1

Application of 57946-63-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 57946-63-1 as follows.

Commercially available 2-bromo-4-(trifluoromethyl)benzeneamine (2.06 g, 8.6 mmol) was suspended in concentrated HCl (4.0 mL). Clumps of material were broken up with a spatula, then ice (-2.6 g) was added to the mixture and it was cooled over an ice bath. A solution of NaNO2 (0.64 g, 9.3 mmol) in H2O (2.6 mL) was added dropwise while maintaining the temperature of the reaction mixture at 0-50C. The mixture was stirred for 20 minutes over the ice bath, then poured slowly into a solution of KI (12.5 g, 75.3 mmol) in H2O (16 mL). The BCI mixture was stirred for several minutes, then left to settle over night. EPO The reaction mixture was extracted thrice with hexanes. The combined organics were washed twice with IM NaOH, once with aqueous sodium bisulfite solution, then with brine. The solution was dried over MgSO4, vacuum filtered through Celite.(R). and cone in vacuo to give 2.33 g of 2-bromo-4-(trifluoromethyl)-iodobenzene. By TLC (100percent hexanes) and 1H NMR analysis, it was determined that the product was of sufficient purity to be used in the subsequent step. The resultant diethyl [2-bromo-4-(trifluoromethyl)- phenyljdifluoromethylphosphonate was synthesized from 2-bromo-4-(trifluoromethyl)- iodobenzene according to Example 25 except that chlorotrimethylsilane (several drops) was used in place of acetic acid. Compound 86 was synthesized according to procedures similar to those of Example 40 from this corresponding diethyl phosphonate. MS (ES-):m/z 352.9, 354.9 (M – H). 1H NMR: (DMSO-d6, 400 MHz) delta 8.07 (s, IH), 7.89 (d, J = 8.0, IH), 7.78 (d, J = 8.0, IH).

According to the analysis of related databases, 57946-63-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CEPTYR, INC.; WO2006/55525; (2006); A2;,
Bromide – Wikipedia,
bromide – Wiktionary