Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 67344-77-8, name is 1-(3-Bromophenyl)-N-methylmethanamine, A new synthetic method of this compound is introduced below., category: bromides-buliding-blocks
Step 1 : N-(3-Bromobenzyl)-N-methylacetamideTo a DMF (0.1 M) solution of 3-bromo-N-methylbenzylamine (1 eq.), Hunig’s base (3 eq) and 4-(dimethylamino)pyridine (5percent loading) was added acetyl chloride (1.5 eq). The resulting reaction mixture was stirred at RT for 16 h. After quenching the reaction with sat. aq. NaHCO3, the mixture was extracted with EtOAc. The organic extract was washed with 10percent aq. HCl, sat. aq. NaHCO3, and brine. Drying over Na2SO4, filtration and concentration of the filtrate in vacuo afforded the crude product as a yellow oil. Purification by way of flash chromatography (SiO2, 4: 1 (v/v) Hex : EtOAc -> EtOAc) afforded the title compound as a yellow oil.
The synthetic route of 67344-77-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK FROSST CANADA LTD.; WO2007/9250; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary