In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 944718-31-4, name is 5-Bromo-1-methyl-1H-benzo[d][1,2,3]triazole belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 5-Bromo-1-methyl-1H-benzo[d][1,2,3]triazole
A mixture of 5-bromo-l-methyl-liT-benzo[7][l,2,3]triazole (302.3 mg, 1.426 mmol), diphenylmethanimine (342.5 mg, 1.890 mmol), t-BuONa (274.2 mg, 2.853 mmol), BINAP (87.8 mg, 0.141 mmol) and Pd2(dba)3 (131.4 mg, 0.1435 mmol) in l,4-dioxane (10 mL) was heated to 100 °C and stirred for 6 hours under N2 atmosphere and concentrated in vacuo. The residue was diluted with water (50 mL) and the resulting mixture was extracted with a mixed solvent of DCM/MeOH (10/1 (v/v), 80 mLx 3). The combined organic layers were dried over anhydrous Na2S04 and concentrated in vacuo to give the title compound as a brown solid (445.4 mg), which was used directly in the next step without further purification. MS (ESI, pos.ion) m/z: 313.2 [M+H]+.
The synthetic route of 944718-31-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Minxiong; PENG, Ju; LI, Xiaobo; ZHANG, Tao; HU, Haiyang; CHEN, Wuhong; BAI, Changlin; KE, Donghua; CHEN, Peng; (281 pag.)WO2019/99311; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary