Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2924-09-6, name is 5-Bromo-2-fluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., name: 5-Bromo-2-fluoroaniline
Under an argon atmosphere, 5-bromo-2-fluoro stirring by addition of water (120mL) to the aniline (45.6g, 240mmol) and, after the addition of concentrated hydrochloric acid (120mL), cooled to -20 , and sodium nitrite ( 19.9g, was added dropwise an aqueous solution of 288mmol) and water (80mL). After stirring 20 minutes at -20 ,Adding an aqueous solution of potassium iodide (59.8g, 360mmol) and water (60mL), andIt was stirred for 30 minutes. After extraction with hexane, the organic layer was washed with saturated aqueous sodium hydrogen carbonate solution, sodium sulfite solution and dried over sodium sulfate, the solvent was evaporated under reduced pressure. The residue was purified by a silica gel column chromatographyPurified5-Bromo-2-fluoro-iodobenzene (54.6g, 181mmol)(Yield: 76%).
According to the analysis of related databases, 2924-09-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Idemitsu Kosan Corporation; Hayama, Tomoharu; Kawamura, Masahiro; Mizuki, Yumiko; Ito, Hirokazu; Haketa, Tasuku; (50 pag.)KR2016/18458; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary