These common heterocyclic compound, 39478-78-9, name is 5-Bromo-2-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H8BrN
Step A: N-(5-bromo-2-methylphenyl)-3,3-dimethylbutanamide 3,3-Dimethylbutanoyl chloride (1.0 g, 5.4 mmol) was added to a solution of 5-bromo-2-methylaniline (0.796 g, 5.9 mmol) in acetonitrile (10 mL). The reaction mixture was stirred at room temperature overnight. Water was added to the mixture and the precipitate formed collected to yield the title compound (0.9 g, 60%) as a white powder.
The synthetic route of 5-Bromo-2-methylaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Valeant Pharmaceuticals North America; US2008/45534; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary