Electric Literature of 626-88-0, The chemical industry reduces the impact on the environment during synthesis 626-88-0, name is 1-Bromo-4-methylpentane, I believe this compound will play a more active role in future production and life.
[008191 Prepared using General Procedure 12: To a stirred solution of tert-butyl (8)-i – (2-(5-Qert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-hydroxyphenyl)pyrimidin-2- yl)phenyl)propanoyl)azetidine-3-carboxylate (INT-48) (300 mg, 0.479 mmol) in DMF (5mL) was added Cs-CO3 (197 mg, 0.58 mrnol) and 1-bromo-4-methylpentane (158 mg, 0.96 mmol). The reaction mixture was stirred for 18 h at 65C then diluted with aq. NaHCO3 (100 ml, saturated) and extracted with EA (2 X 100 mL). The combined organic layers were dried (Na2SO4), concentrated, and purified by column chromatography (EA/ hexane)to afford 188 mg (54%) of tert-butyl (S-1-(2-(5-(tert- butyl)thiophene-2-carboxarnido)-3-(4-(5 -(4-((4-methylpentyl) oxy)phenyl)pyrimidin-2- yl)phenyl)propanoyl)azetidine-3 -carboxylate .LCMS-ESI (m/z) calculated for C42H52N4O5S 724.96; found 725.3 [M±H] , /p. = 12.71 mm (Method 16). ?H NMR (400 MHz, CDC13) oe 8.97 (d, J = 7.5 Hz, 2H). 8.45 (d, J = 5.5 Hz, 2H), 7.55 (s, 2H). 7.49 – 7.31 (rn. 3H), 7.05 (d, J 6.6 Hz, 2H), 6.82 (s, IH), 6.68 (d, J= 28.8 Hz, 1H), 4.82 (s, 1H). 4.30 (s. 0.5H). 4.07 (rn, 5.5H), 3.56 (s, 0.5H), 3.31 – 3.09 (rn, 2H), 2.91 (s, 0.5H),1.83 (s, 2H), 1.60 (d, J= 25.3 Hz, 1H), 1.40 (s, 16H), 1.29 (s, 4H), 0.95 (s, 6H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-methylpentane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CELGENE INTERNATIONAL II SARL; BOEHM, Marcus, F.; MARTINBOROUGH, Esther; MOORJANI, Manisha; TAMIYA, Junko; HUANG, Liming; YEAGER, Adam, R.; BRAHMACHARY, Enugurthi; FOWLER, Thomas; NOVAK, Andrew; MEGHANI, Premji; KNAGGS, Michael; GLYNN, Daniel; MILLS, Mark; (851 pag.)WO2016/94729; (2016); A1;,
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