Application of 401-84-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 401-84-3, name is 1,3-Dibromo-5-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows.
l,3-dibromo-5-(trifluoromethyl)benzene (1, 3.03 g, 10.00 mmol) was dissolved in dry diethyl ether (25 mL) and cooled to -78C. n-Butyllithium (4.24 mL, 2.35 M in hexanes, 10.0 mmol) was added drop-wise with stirring. After 15 minutes, dry N,N- dimethylformamide (1.44 mL, 20.0 mmol) was added in one portion and the resulting mixture was allowed to warm to ambient temperature over an hour. 1 M aqueous solution of hydrochloric acid (30 mL) was then added to quench the reaction and the reaction mixture was taken up in diethyl ether (30 mL) and washed with water (20 mL) and brine (20 mL), dried over anhydrous sodium sulfate, filtered and evaporated. The crude product was purified by flash column chromatography (Silicagel 60, 0.040-0.063 mm; eluent: cyclohexane/ethyl acetate 20: 1) to give 3-bromo-5-(trifluoromethyl) benzaldehyde (2) as colorless oil. Yield : 1366 mg (54%). JH NMR spectrum (300 MHz, CDCI3, deltaEta) : 10.02 (s, 1 H); 8.20 (bs, 1 H); 8.07 (bs, 1 H); 8.02 (bs, 1 H).
The chemical industry reduces the impact on the environment during synthesis 1,3-Dibromo-5-(trifluoromethyl)benzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; NOVO NORDISK A/S; KRUSE, Thomas; HANSEN, Mikael, Kofoed; MUeNZEL, Martin, Werner, Borchsenius; THØGERSEN, Henning; SAUERBERG, Per; RASMUSSEN, Jakob, Ewald; BEHRENS, Carsten; HØEG-JENSEN, Thomas; BAL?ANEK, Vojtech; DROBNAKOVA, Zuzana; DRO?, Ladislav; HAVRANEK, Miroslav; KOTEK, Vladislav; ?TENGL, Milan; ?NAJDR, Ivan; VANOVA, Hana; (202 pag.)WO2019/92125; (2019); A1;,
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bromide – Wiktionary